Final answer:
Among the options presented, hypothermia is the most indicative sign of neonatal sepsis. Neonatal sepsis can present with various symptoms including temperature instability, and early recognition and treatment are critical.
Step-by-step explanation:
The most indicative sign of sepsis in a neonate among the given options is C) Hypothermia. Neonatal sepsis can present with various symptoms, including temperature instability which may manifest as either fever or hypothermia. Hypothermia in a neonate can be a particularly alarming sign and warrants immediate medical attention. The clinical signs of sepsis in neonates can also include apnea, bradycardia, hypotension, difficulty feeding, irritability, and limpness. It is crucial for healthcare providers to recognize these signs early as neonatal sepsis is a serious medical condition that can rapidly progress and lead to severe complications or death.