Final answer:
Endometrial cancer after age 50. This hormone imbalance can happen if a woman experiences an overproduction of estrogen without sufficient progesterone to balance it.
Step-by-step explanation:
Hormone imbalance, specifically an excess of estrogen relative to progesterone, is a potential risk factor for endometrial cancer in women over the age of 50. Estrogen stimulates the growth of the endometrium (lining of the uterus), and in the absence of adequate progesterone, it can lead to uncontrolled cell growth and an increased risk of cancer.
Estrogen dominance can result from various factors, such as obesity, hormonal therapy without progesterone, or conditions like polycystic ovary syndrome (PCOS). The lack of balance between estrogen and progesterone disrupts the normal regulation of the endometrial tissue, potentially contributing to the development of endometrial cancer.