Final answer:
The reference range for uric acid in micromoles/L is typically 142 to 339 micromoles/L. High levels can lead to gout, where uric acid forms painful crystals in joints. Regular monitoring is important for managing diseases related to uric acid metabolism.
Step-by-step explanation:
The reference range for uric acid in the blood, when measured in micromoles per liter (micromoles/L), is typically around 142 to 339 micromoles/L (2.4 to 5.7 mg/dL for females and 3.4 to 7.0 mg/dL for males). These values can depend on a variety of factors, such as laboratory standards and patient demographics. A high concentration of uric acid in the blood, such as levels exceeding 7 mg/dL, can lead to conditions like gout, as the uric acid may precipitate as sodium ureate crystals. These can get deposited in joints and soft tissues, causing pain and inflammation.
Uric acid is formed in the body through the metabolism of purines, which are hydrolysed in the liver and eventually oxidized to uric acid. The estimation of blood uric acid levels can be done through various methods including the phosphotungstic acid method, Fehling's method, and usage of autoanalyzers. Regular monitoring of uric acid levels plays a crucial role in aiding the diagnosis of diseases related to uric acid metabolism, such as gout and von Gierke's disease.