Final answer:
The modified position on the anticodon that allows wobble interactions is the first base at the 5' end, often being inosine (I). This base can pair with multiple codon nucleotide bases, enabling one tRNA to recognize several codons for the same amino acid.
Step-by-step explanation:
The position on the anticodon that is modified to allow the wobble interaction is the first base at the 5' end of the anticodon (also referred to as the wobble position). This modified nucleoside is often inosine (I), which can pair with more than one type of nucleotide on the mRNA codon, including uracil (U), cytosine (C), and adenine (A). Such modifications facilitate the binding of the tRNA to multiple codons that code for the same amino acid, a crucial aspect of the genetic code's redundancy and the efficiency of protein synthesis.
Diverse chemical modifications to the anticodon's wobble base, like the formation of restricted *UNN anticodons or the presence of a G-U wobble pair near the 3' acceptor end, increase the capacity of a single tRNA species to recognize multiple codons. Scientific understanding of these modifications and their impact on mRNA codon-anticodon interaction have evolved through studies such as those cited from researchers McClain and Foss, Yokoyama and Nishimura, and others.
Modifications such as a uridine base in the wobble position being modified to a pseudouridine or a deoxyinosine contribute to the phenomena of wobbling and the resultant balance between specificity and versatility in genetic code translation.