Question

When a tissue is injured, a series of well-coordinated events occurs including vascular and cellular responses, formation of inflammatory exudates, and tissue repair. Acute inflammation is an immediate response to an injury. Rapid vasodilatation occurs, allowing more blood near the location of the injury. An injury causes tissue damage and possibly necrosis. As a result, the body releases chemical mediators that increase the permeability of small blood vessels; thus fluid, protein, and cells enter interstitial spaces. The accumulation of fluid appears as localized swelling. The accumulation of fluid, dead tissue cells, and white blood cells (WBCs) form an exudate at the site of inflammation. In the last step of tissue repair, granulation tissue formation occurs.

a. true
b. false

Answer 1

The inflammatory response to tissue injury involves the release of chemical mediators, which leads to vasodilation, increased permeability, swelling, and pain. This sets the stage for the immune system to contain the injury and begin tissue repair, although the recovery varies among different tissues. Anti-inflammatory drugs can assist in reducing inflammation and pain.

Step-by-step explanation:

Inflammatory Response to Tissue Injury

When tissue injury occurs, the body launches an inflammatory response. Damage to cells leads to the release of various inflammatory chemical mediators like histamine, prostaglandins, and leukotrienes, which cause local blood vessels to dilate (vasodilation) and become more permeable. This allows white blood cells (WBCs), fluid, and proteins to move into the interstitial space, leading to swelling or edema and pain, as well as warmth and redness at the site. Dead tissue and WBCs form what's known as inflammatory exudate, which aids in containing the injury and preventing the spread of infection.

Following the initial response, the body begins to repair the damaged tissue. Collagen fibers are laid down by fibroblasts, leading to the formation of granulation tissue. This marks the beginning of the healing process, although the regenerative capacity varies among different tissue types. While epithelial and connective tissues have the ability to regenerate efficiently, muscle and nervous tissues may not repair as readily or at all. The use of anti-inflammatory drugs such as NSAIDs can help reduce inflammation and pain by inhibiting the production of prostaglandins.