Final answer:
During George Washington's presidency, the least important domestic issue he faced was the debate over supporting domestic manufacturing.
Step-by-step explanation:
During George Washington's presidency, he faced various domestic problems, each with different levels of importance. However, the least important issue can be considered as the debate over supporting domestic manufacturing. While Hamilton proposed supporting domestic manufacturing, Washington did not consider it necessary and did not support the proposals. Although Washington recognized the importance of a balance between agriculture and industry in the United States, he believed that self-sufficient yeoman farmers would make the nation great, making the proposed support for domestic manufacturing unnecessary in his view.