Question

Which of the following is or are expected findings in beta thalassemia minor?

a. normocytic normochromic red cells
b. basophilic stippling
c. hemoglobin levels in the 4 to 6 g/dL range
d. normal levels of Hb F and A2

Answer 1

Beta thalassemia minor typically presents with microcytic, hypochromic red cells, basophilic stippling, and mild to moderate anemia with hemoglobin levels usually above 4 to 6 g/dL range. Elevated levels of HbA2 and HbF are common findings, not normal levels.

Step-by-step explanation:

In beta thalassemia minor, the expected findings would typically include microcytic, hypochromic red blood cells (smaller and paler than normal) due to the decrease in the synthesis rate of the beta chain of hemoglobin, leading to an excess of alpha chains. These excess alpha chains can form unstable tetramers (alpha-4 globin) or combine with delta and gamma chains, increasing the levels of HbA2 and HbF. It is also common to observe basophilic stippling of red cells and a mild to moderate anemia with hemoglobin levels above the range of 4 to 6 g/dL. In beta thalassemia minor, unlike severe forms of thalassemia, the levels of HbF and HbA2 are often elevated. Therefore, we would not expect to see normal levels of HbF and HbA2. Hemoglobin levels may be slightly reduced but not as low as 4 to 6 g/dL which is associated with more severe anemia conditions.