Question

Secondary cold reactive autoimmune hemolytic anemia is found most often in patients with:

Answer 1

Secondary cold reactive autoimmune hemolytic anemia is found most often in patients with systemic lupus erythematosus (SLE).

Step-by-step explanation:

Secondary cold reactive autoimmune hemolytic anemia is found most often in patients with systemic lupus erythematosus (SLE), a systemic disorder characterized by type III hypersensitivity reactions. In SLE, autoantibodies are produced against nuclear and cytoplasmic proteins, leading to the formation of immune complexes. These immune complexes can accumulate in the blood vessels and organs, including the kidneys, joints, and others, causing inflammation and activation of complement proteins.

Patients with SLE often have elevated levels of autoantibodies, including anti-nuclear antibodies (ANAs), anti-double-stranded DNA (ds-DNA) antibodies, and anti-smooth muscle (Sm) antibodies. The presence of these autoantibodies is included in the classification criteria for SLE.