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Which of the following would be an unexpected finding for patients with hemoglobin SC disease or s/B⁰- thalassemia?

-target cells
-shortened red cell survival
-normal tube solubility test
-mild to moderate clinical features

1 Answer

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Final answer:

A normal tube solubility test would be an unexpected finding for patients with hemoglobin SC disease or β0-thalassemia, as these conditions typically show abnormal hemoglobin molecules that affect solubility tests.

Step-by-step explanation:

Among the options provided, the unexpected finding for patients with hemoglobin SC disease or β0-thalassemia would be a normal tube solubility test. Hemoglobin SC disease is a variant of sickle cell disease where individuals have hemoglobin S and C, causing issues like anemia and the presence of sickle shaped cells. β-thalassemia is characterized by reduced synthesis of the β-globin chain of hemoglobin, leading to anemia and other related symptoms. Both disorders typically show abnormal hemoglobin solubility tests due to the presence of abnormal hemoglobin molecules.

Target cells, a shortened lifespan of red blood cells, and mild to moderate clinical features are common in both conditions and are therefore expected. A normal tube solubility test, which primarily detects the presence of hemoglobin S, would not essentially reflect the normal solubility of other hemoglobin variants and would count as an unexpected result for people with these hemoglobinopathies.

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