Final answer:
The common feature of myelodysplastic syndromes (MDSs) is progressive cytopenias and dyspoiesis in one or more cell lines. (option B)
Step-by-step explanation:
A common feature of the myelodysplastic syndromes (MDSs) is progressive cytopenias and dyspoiesis in one or more cell lines. MDSs are a group of disorders caused by poorly formed or dysfunctional blood cells due to dysplastic changes in the bone marrow. Patients with MDS can present with various degrees of anemia, neutropenia, and thrombocytopenia, reflecting ineffective hematopoiesis and disrupted maturation of blood cells. In contrast to peripheral blasts between 5% and 20%, which is more indicative of acute leukemias, MDS often features macrocytic red cells due to disrupted DNA synthesis.
Acute myelogenous leukemia (AML) is a cancer where patients would experience impaired production of erythrocytes due to the clonal expansion of malignant myeloid precursor cells. These cells often crowd out the normal hematopoietic progenitors, leading to decreased erythrocyte production. Furthermore, the growth factors such as thrombopoietin that stimulate the proliferation of megakaryoblasts ultimately form platelets that can also be affected by the dysregulation in MDS and leukemia.