Final answer:
Cocaine withdrawal is associated with a depletion of dopamine, leading to a pleasureless state and cravings for more cocaine.
Step-by-step explanation:
The depletion of dopamine leads to the "crash" associated with cocaine withdrawal. Cocaine acts as a stimulant by preventing nerve cells from taking up dopamine from the synapse, resulting in high levels of dopamine available to stimulate the pleasure centers of the brain. After the binge, dopamine is depleted in less than an hour, leaving the user in a pleasureless state and craving more cocaine.