Final answer:
Substance dependence can lead to the spread of communicable diseases, premature death, traumatic injuries, and domestic violence.
Step-by-step explanation:
Substance dependence can be a major health issue due to various reasons. It can lead to the spread of communicable diseases like HIV/AIDS and hepatitis C. This is because some substances are often used through sharing needles or engaging in risky sexual behaviors. Additionally, substance dependence can contribute to premature death, as excessive use of substances can lead to organ damage or overdose. Substance dependence can also increase the risk of traumatic injuries, as impaired judgment and coordination can lead to accidents. Moreover, it can contribute to domestic violence, as substance use can affect one's behavior and increase aggression.