Final answer:
When the shape of a protein is altered due to a genetic mutation, the functionality of the protein may be affected.
Step-by-step explanation:
When the shape of a protein is altered due to a genetic mutation, the functionality of the protein may be affected. Proteins have specific three-dimensional shapes that are crucial for their functions. Changes in the shape of a protein can disrupt its ability to catalyze reactions, bind to other molecules, or perform other essential functions.
For example, in sickle cell disease, a mutation results in the replacement of one amino acid in the hemoglobin protein. This change alters the shape of the hemoglobin molecule, leading to its abnormal behavior and causing the symptoms associated with the disease.
Overall, the alteration of a protein's shape due to a genetic mutation can have significant consequences on its ability to carry out its intended functions.