Question

To cause cancer, tumor suppressor genes require 1 (or) 2 allele(s) to be mutated and are therefore considered dominant (or) recessive. This results in _______________ of function.

a) 1; Dominant; Loss
b) 1; Recessive; Gain
c) 2; Dominant; Gain
d) 2; Recessive; Loss

Answer 1

Tumor suppressor genes require mutations in both alleles to cause cancer, making them recessive, and this leads to a loss of function, so the correct answer is d) 2; Recessive; Loss.

Step-by-step explanation:

To cause cancer, tumor suppressor genes require 2 alleles to be mutated and are therefore considered recessive. This results in loss of function. The correct answer to the question is d) 2; Recessive; Loss.

Tumor suppressor genes play a critical role in regulating cell division and preventing cancer. When both alleles of a tumor suppressor gene are mutated, a loss of function occurs, which can fail to regulate cell proliferation and lead to cancer. In contrast, oncogenes are usually dominant and can lead to cancer with a mutation in just one allele because they contain gain-of-function mutations.