Question

The misfolding of proteins is thought to lead to a number of neurological conditions such as Alzheimer's. Which organelle is likely to be involved in this process?

1) Mitochondria
2) Endoplasmic reticulum
3) Golgi apparatus
4) Nucleus

Answer 1

Option 2) is correct answer.The endoplasmic reticulum is likely involved in the misfolding of proteins leading to neurological conditions such as Alzheimer's.

Step-by-step explanation:

The organelle that is likely to be involved in the misfolding of proteins leading to neurological conditions such as Alzheimer's is the Endoplasmic Reticulum. Option 2) is correct answer

Proteins are synthesized in the rough endoplasmic reticulum (RER) and undergo proper folding with the help of chaperone proteins. If the folding process goes awry, misfolded proteins can accumulate in the endoplasmic reticulum. This can trigger a stress response known as the unfolded protein response, leading to cell dysfunction and potentially neurodegenerative diseases.

For example, in Alzheimer's disease, the accumulation of misfolded beta-amyloid protein in the endoplasmic reticulum can contribute to the formation of neurofibrillary tangles and cognitive decline.