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Which is an example of a lipase inhibitor used in the treatment of obesity?

A. phentermine
B. topiramate
C. sibutramine
D. phendimetrazine
E. orlistat

1 Answer

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Final answer:

Orlistat is an example of a lipase inhibitor used for treating obesity by preventing the absorption of fats, thus reducing caloric intake. It inhibits lipase, which is essential for triglyceride digestion.

Step-by-step explanation:

The substance is an example of a lipase inhibitor used in the treatment of obesity is E. orlistat.

Lipase inhibitors are a category of drugs that help treat obesity by preventing the absorption of fats from the diet, thereby reducing caloric intake. Orlistat works by inhibiting the enzyme lipase, which is responsible for breaking down triglycerides in the intestines. Without this enzyme's action, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested. This drug is often prescribed to aid in weight loss and to help reduce the risk of regaining weight already lost. It is important for patients to follow a balanced, calorie-controlled diet that includes around 30% of calories from fat, as orlistat can cause diarrhea, flatulence, and fat-soluble vitamin deficiencies if dietary fat is not controlled.

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