Final answer:
Opechancanough led a series of attacks on English settlements in 1622, following the death of his brother Powhatan, as part of his ongoing effort to expel the English from Virginia. The correct option is B.
Step-by-step explanation:
Four years after the death of his brother, Powhatan, Opechancanough launched a series of attacks on English settlements.
On March 22, 1622, he initiated what would be known as the largest coordinated attack against the English since their arrival in Virginia, resulting in nearly 400 casualties.
This action by Opechancanough was driven by his desire to rid Virginia of English settlers, who he recognized as a growing threat to Indian territories. Despite his efforts, the continued growth and strength of the English colony thwarted his plans to drive them out.
The result was a cycle of conflict that ultimately culminated in Opechancanough's capture and the signing of a treaty in 1646, which ended the two-year conflict and established reservations for the Powhatan tribes. The correct option is B.