Question

Which statement is FALSE?

1) NHEJ very rarely results in insertion or deletion mutations.
2) Nonhomologous end joining (NHEJ) can repair ds breaks.
3) NHEJ is important in the V(D)J recombination of the immune system shuffling.
4) NHEJ requires Ku proteins to bind t

Answer 1

The false statement is that NHEJ very rarely results in insertion or deletion mutations. NHEJ often induces indels during DNA repair and is heavily involved in V(D)J recombination in the immune system.

Step-by-step explanation:

The statement that is FALSE among the options provided is: NHEJ very rarely results in insertion or deletion mutations . Non-homologous end joining (NHEJ) is indeed capable of repairing double-strand breaks in DNA, but this process does not always result in a perfect repair. In fact, NHEJ is prone to introducing insertions or deletions (indels) at the site of repair because it directly rejoins the broken DNA ends without the need for a homologous template. Additionally, NHEJ is an important repair mechanism in the immune system, particularly during V(D)J recombination, where it contributes to the shuffling and diversification of antibody genes. This diversification is critical for the immune system's ability to recognize a wide array of antigens. NHEJ does indeed require the Ku proteins to bind to the broken DNA ends and initiate the repair process.