Question

Indicate true (T) and false (F) statements below regarding glycosylation of proteins in the endoplasmic reticulum and the Golgi apparatus. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF

1 Glycosylation can promote protein folding.
2 The glycosylation state of a protein can determine its fate along the secretory pathway.
3 Glycosylation makes a protein more accessible to proteases and other proteins.
4 Glycosylated proteins are generally more flexible.

Answer 1

Glycosylation of proteins in the endoplasmic reticulum and the Golgi apparatus can promote protein folding and determine the fate of the protein along the secretory pathway. However, it does not make the protein more accessible to proteases or increase flexibility.

Step-by-step explanation:

The statement 'Glycosylation can promote protein folding' is true (T). Glycosylation is a process in which sugars are covalently attached to proteins. This modification can stabilize the protein structure and facilitate proper folding.

The statement 'The glycosylation state of a protein can determine its fate along the secretory pathway' is true (T). The addition or removal of sugars during glycosylation can influence how the protein is sorted and targeted to specific cellular destinations.

The statement 'Glycosylation makes a protein more accessible to proteases and other proteins' is false (F). Instead, glycosylation can actually provide protection against proteases and increase protein stability.

The statement 'Glycosylated proteins are generally more flexible' is false (F). Glycosylation can introduce steric hindrance and reduce protein flexibility.