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Which negatively charged ion is predominantly found outside the cell to balance the net positive charge resulting from metal ions like K⁺, Na⁺, and Ca₂⁺, and what is the primary ion it often neutralizes (indicated in parentheses)?

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Final answer:

Chloride ion (Cl-) is predominantly found outside the cell to balance the net positive charge resulting from metal ions like K⁺, Na⁺, and Ca²⁺.

Step-by-step explanation:

The negatively charged ion that is predominantly found outside the cell to balance the net positive charge resulting from metal ions like K+, Na+, and Ca2+ is chloride ion (Cl-). Chloride ions primarily neutralize the net positive charge by accumulating outside the cell, where they are repelled by negatively-charged proteins within the cytoplasm.

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