Question

Which of the following is TRUE of Sertoli cells, but not granulosa cells?

1) secretes paracrines that support gamete development
2) provides nutrients for developing gametes
3) forms a barrier between the fluid surrounding the gamete and blood
4) secretes inhibin
5) secretes androgen-binding protein

Answer 1

The correct answer is that Sertoli cells secrete androgen-binding protein, which is not a function of granulosa cells. This is represented by option 5 in the question, distinguishing Sertoli cells from granulosa cells.

Step-by-step explanation:

The student asked which of the following is TRUE of Sertoli cells, but not granulosa cells:

1. secretes paracrines that support gamete development
2. provides nutrients for developing gametes
3. forms a barrier between the fluid surrounding the gamete and blood
4. secretes inhibin
5. secretes androgen-binding protein

Sertoli cells fulfill several functions in the process of spermatogenesis, which include providing nutrients for developing gametes, forming a blood-testis barrier (option 3), secreting signaling molecules that promote sperm production, and secreting androgen-binding protein (option 5). While granulosa cells also provide nutrients and secrete inhibin, the primary distinction between Sertoli cells and granulosa cells is that Sertoli cells form the blood-testis barrier and secrete androgen-binding protein. Therefore, the correct answer is option 5: Sertoli cells secrete androgen-binding protein, which is not a function of granulosa cells.