Final answer:
Lamina-associated domains (LADs) are regions of chromosomes which come in contact with the nuclear lamina, providing structural support in the cell nucleus.
Step-by-step explanation:
Lamina-associated domains (LADs) are regions of chromosomes found in close contact with the nuclear lamina in eukaryotic cells. The nuclear lamina is a meshwork of intermediate filaments, predominantly consisting of lamins, that's located just inside the nuclear envelope. Its role is to provide structural support to the nucleus. Chromosomes are formed from chromatin, which is a complex of DNA and proteins, including histones that help in packaging the DNA into a compact, organized form within the nucleus.
DNA within the nucleus exists in two main forms during interphase: heterochromatin and euchromatin. Heterochromatin is highly condensed, contains genes that are not actively transcribed, and is often found in association with the nuclear lamina as LADs. Meanwhile, euchromatin is less condensed and contains genes that are typically being transcribed.