Final answer:
Rabs bound to GTP recruit specific cytosolic tethering proteins to membrane surfaces, which is a crucial step in the vesicle targeting and fusion process in cellular transport.
Step-by-step explanation:
When Rabs are bound to GTP, they recruit specific cytosolic tethering proteins to specific membrane surfaces. This process is essential for the correct targeting and fusing of vesicles with their target membranes, aiding transport of compounds within the cell.
Upon GTP binding, Rab proteins induce the assembly of tethering complexes at the surface of distinct membranes. These complexes then mediate the initial contact between vesicles and their target membranes. Following this, SNARE proteins, both v-SNARE on the vesicle and t-SNARE on the target membrane, come into play. They interact to facilitate membrane fusion which allows the vesicle contents to be delivered to their intended location.
This intricate process ensures that proteins and lipids are accurately and efficiently transported to their required cellular destinations, which is vital for maintaining the correct cellular function.
When Rabs have bound to GTP, they recruit specific cytosolic tethering proteins to specific membrane surfaces. This process allows the Rabs to help sort specific packaged proteins and fuse membranes together. The fusion occurs when V-SNARE proteins on vesicles bind to complementary T-SNARE proteins on receiving membranes. This fusion enables the transport of proteins to their final destinations.