Final answer:
President Andrew Jackson's statement is most likely (d) regarding the South Carolina Nullification Crisis, during which he took a decisive stand to preserve the Union against South Carolina's claim of the right to nullify federal tariffs.
Step-by-step explanation:
The issue on which President Andrew Jackson most likely made the statement in question seems to reflect his stance on the South Carolina Nullification Crisis that erupted as a result of new tariffs. The tariffs of 1828 and 1832 were highly controversial and caused great consternation in the South, particularly in South Carolina.
Jackson's strong stand on preserving the Union was evident when he faced down South Carolina's claim that states had the right to nullify federal laws. His actions during this crisis exemplified his commitment to a robust nationalism, even as he also supported restraint on federal power in other aspects of governance.