Final answer:
Enzymes are sensitive to changes in temperature and pH. Deviating significantly from an enzyme's optimum level can affect its shape and function, leading to denaturation. High temperatures and extreme pH values can cause enzymes to denature.
Step-by-step explanation:
Enzymes are proteins that are sensitive to changes in temperature and pH. If the temperature or pH significantly deviates from an enzyme's optimum level, it can affect the enzyme's shape and function. High temperatures can cause enzymes to denature, leading to a loss of their three-dimensional structure and function. Extreme pH values can also cause enzymes to denature and become less effective.