Question

You are studying cells in the lab, and discover a cell that has a mutation that prevents transcription of kinetochore genes. The cell would:

1) replace its microtubules with actin to survive.
2) be deficient in lining up mitotic chromosomes during metaphase.
3) contain shorter polar microtubules.
4) have fewer astral microtubules.
5) not be able to replicate its genome.

Answer 1

A mutation that prevents transcription of kinetochore genes would lead to a deficiency in lining up mitotic chromosomes during metaphase, affecting the cell's ability to properly divide.

Step-by-step explanation:

If a cell has a mutation that prevents transcription of kinetochore genes, this would mean that the kinetochores would not form properly on the sister chromatids during cell division. Without functional kinetochores, the mitotic spindle microtubules would not be able to attach to the chromosomes.

This would lead to a deficiency in lining up mitotic chromosomes during metaphase. Kinetochores are essential for the correct alignment and separation of sister chromatids, so such a mutation would impact mitotic chromosome alignment but would not directly affect genome replication or microtubule composition with actin.