Final answer:
The false statement regarding renal handling of glucose is that the maximum rate of glucose reabsorption is 375 mg/min, as this rate can vary between genders. Glucose reabsorption occurs in the proximal convoluted tubule and is exceeded when plasma glucose levels go beyond the renal threshold, leading to glucosuria.
Step-by-step explanation:
The statement that is FALSE concerning renal handling of glucose is: 1) The maximum rate of glucose reabsorption is 375 mg/min. Glucose reabsorption in the kidney occurs at a maximum rate of about 375 mg/min in men and approximately 300 mg/min in women. This rate corresponds to a plasma glucose concentration of about 200 mg/dL. Glucose is actively reabsorbed in the proximal convoluted tubule (PCT), and when plasma glucose levels exceed the renal threshold of about 180 mg/100 ml, glucose begins to appear in the urine, a condition known as glucosuria.
Glucose is reabsorbed by a process that involves sodium-glucose cotransporters on the apical surface of the PCT cells. This cotransport with Na+ utilizes the energy from the Na+/K+ ATPase on the basal surface of the cells. If glucose concentration in the plasma exceeds the renal threshold, it cannot be completely reabsorbed, and glucose will appear in the urine even if its concentration is less than the mentioned transport maximum (Tm).