Question

Which of the following statements is NOT true of integrins? They:

1) are solely components of the extracellular matrix
2) serve as adhesion molecules
3) relay signals between the cell and the extracellular matrix
4) impart polarity to the cell

Answer 1

Integrins mainly facilitate cell-matrix adhesion and interact with the extracellular matrix, but they do not impart polarity to the cell. Polarity involves other cellular components and integrins play a role in cell migration and signaling.

Step-by-step explanation:

The statement that is NOT true about integrins is that they impart polarity to the cell. In biology, integrins are integral membrane proteins that facilitate cell-matrix adhesion, signal transduction, and play a role in cell migration and tissue architecture. However, imparting polarity to the cell is not typically attributed as a function of integrins. Polarity involves other cellular components and mechanisms that contribute to an asymmetric organization within the cell, defining distinct structural and functional regions.

Integrins primarily interact with the extracellular matrix (ECM) and are connected to the actin cytoskeleton within the cell. Through their role in focal adhesions, integrins help to mediate the force balance between the inside of the cell and the external environment, influencing cell shape, movement, and signaling pathways. Integrins can influence cell differentiation during embryogenesis by responding to ECM components like fibronectin, and this response includes the formation of appropriate cell junctions and associated gene expression.