Final answer:
Ligand-gated ion channels have the ability to change the permeability of the membrane to certain ions when the ligand binds.
Step-by-step explanation:
True. Ligand-gated ion channels are a type of cell-surface receptor that open when a ligand (signaling molecule) binds to them. This binding causes a conformational change in the channel protein, allowing specific ions to pass through the membrane by changing its permeability. For example, neurotransmitters like acetylcholine can bind to ligand-gated ion channels and open the pore, allowing cations of sodium, calcium, and potassium to pass through.