Final answer:
The transcription factor that induces the expression of IFN-gamma in a CD4 TH1 cell is T-bet. Expression of IFN-gamma in a CD4 TH1 cell is directed by the transcription factor T-bet. TH1 cells are key in the immune response against intracellular pathogens, activating other immune cells for defense. Additionally, the clonal selection of B cells occurs in the TH2 pathway, aiding in the production of specific antibodies.
Step-by-step explanation:
Expression of IFN-gamma is induced in a CD4 TH1 cell under the direction of the transcription factor T-bet. T-bet is a master regulator of the TH1 cell lineage and controls the production of IFN-gamma. When a CD4 TH1 cell is activated, T-bet is upregulated and initiates the transcription of IFN-gamma gene.
Expression of IFN-gamma in a CD4 TH1 cell is directed by the transcription factor T-bet. TH1 cells are key in the immune response against intracellular pathogens, activating other immune cells for defense. Additionally, the clonal selection of B cells occurs in the TH2 pathway, aiding in the production of specific antibodies.
Expression of IFN-gamma is induced in a CD4 TH1 cell under the direction of the transcription factor T-bet. The TH1-mediated response is an integral part of the adaptive immune system which includes the activation of macrophages and is associated with inflammation. When presented with pathogens like Mycobacterium tuberculosis, macrophages activate naïve T cells into TH1 cells. These TH1 cells then release cytokines that boost the macrophages' ability to digest the pathogen. TH1 cells, therefore, play a pivotal role in the immune response against intracellular pathogens by stimulating other immune cells such as cytotoxic T cells, macrophages, and NK cells.
Conversely, the TH2-mediated response involves B lymphocytes which differentiate into plasma cells and secrete antibodies when activated via the TH2 pathway. This process, known as clonal selection, results in a proliferation of B cells specific to the infecting pathogen. Helper T lymphocytes are vital in the immune response, binding to antigen-presenting cells (APCs), and releasing cytokines to initiate the immune response, including the differentiation of naïve helper T cells into diverse subtypes such as TH1 and TH2 cells.