Final answer:
In the absence of a drug, the synapse becomes less sensitive.
Step-by-step explanation:
In the absence of a drug, the synapse becomes less sensitive.
When a drug is not present, the synapse functions normally and responds to neurotransmitters appropriately. However, the presence of certain drugs can alter the sensitivity of the synapse, leading to drug dependence.
For example, repeated exposure to drugs like opioids or benzodiazepines can cause changes in the brain that result in decreased sensitivity of the synapse. As a result, higher doses of the drug are needed to achieve the same effect, leading to drug dependence.