Final answer:
Enzymes are vital for metabolic processes, and their absence disrupts normal biological pathways, leading to enzyme-deficiency disorders like Gaucher disease, where toxic substrates accumulate, causing harm to the body.
Step-by-step explanation:
The lack of an enzyme leads to problems observed in patients with Gaucher disease because enzymes are crucial for metabolic processes within the body. When an enzyme is absent, as in the case with Gaucher disease, the normal biological pathway is disrupted, leading to the accumulation of toxic substrates or the insufficient production of necessary products.
For instance, in enzyme-deficiency disorders like Gaucher disease, the deficiency in the enzyme glucocerebrosidase results in the harmful accumulation of glucocerebroside within cells, particularly affecting the spleen, liver, and bone marrow. Similar to the issues arising in other disorders such as G6PD deficiency, where the lack of glucose-6-phosphate dehydrogenase enzyme leads to red blood cells' vulnerability to oxidative damage and results in hemolytic anemia.