Question

Naive lymphocytes homing to lymphoid tissue use _____ to bind to CD34 and GlyCAM-1 on high endothelial venules (HEV).

1) L-selectin
2) CD2 (LFA-2)
3) ICAM-1
4) CCl₂1
5) CD28

Answer 1

Naive lymphocytes use L-selectin to bind to CD34 and GlyCAM-1 on high endothelial venules (HEV) in lymphoid tissue, which is crucial for immune surveillance and lymphocyte activation.

Step-by-step explanation:

Naive lymphocytes homing to lymphoid tissue utilize L-selectin to bind to CD34 and GlyCAM-1 on high endothelial venules (HEV). The process of lymphocyte trafficking through HEVs is essential for immune surveillance and the activation of naive lymphocytes.

L-selectin acts as a homing receptor for the lymphocytes, facilitating their migration into the lymph nodes. This interaction plays a crucial role in the immune system's response to pathogens by ensuring that the lymphocytes effectively locate the lymph node environment where they may encounter antigens and become activated.