Question

Binding of _____ to _____ induces T-cell proliferation and differentiation of activated T cells.

1) CD4; MHC class II
2) CD28; B7
3) LFA-1; ICAM-1
4) IL-2; the high-affinity IL-2 receptor
5) IL-2; the low-affinity IL-2 receptor

Answer 1

IL-2 binding to the high-affinity IL-2 receptor leads to T-cell proliferation and differentiation, an essential step in the immune response.

Step-by-step explanation:

The binding of IL-2 to the high-affinity IL-2 receptor induces T-cell proliferation and differentiation of activated T cells. This interaction is crucial for the immune response as IL-2 is a key growth factor for T cells. The high-affinity IL-2 receptor is expressed on the surface of T cells upon activation, and its engagement by IL-2 leads to T cell proliferation and differentiation into effector and memory cells.