87.2k views
3 votes
All of the following are correctly matched except _____?

1) T1: T-bet
2) Treg: FoxP3
3) IL-12: dendritic cells
4) TH17: RORgammaT
5) TH₂: Bcl6

User Jecki
by
6.9k points

1 Answer

3 votes

Final answer:

In the student's question regarding the matching of T cell subsets to their characteristic markers, 'TH2: Bcl6' is the incorrect pairing. TH2 cells are characterized by the expression of GATA3, not Bcl6, which is associated with Tfh cells.

Step-by-step explanation:

The student's question is about the specific associations between different types of T cells and their characteristic proteins or cytokine products. The options provided match specific T cell subsets to transcription factors or cytokine-producing cells except one.

  • T1 cells and T-bet: T1 cells (Th1) are characterized by the expression of the transcription factor T-bet.
  • Regulatory T cells (Treg) and FoxP3: Treg cells are characterized by the expression of FoxP3, a transcription factor that is vital for their function.
  • IL-12 and dendritic cells: Dendritic cells are among the cells that produce IL-12, a cytokine important for the differentiation of naive T cells into Th1 cells.
  • TH17 cells and RORgammaT: The differentiation of TH17 cells is dependent on the transcription factor RORgammaT.
  • TH2 cells and Bcl6: However, the TH2 cells are not characterized by the expression of Bcl6, this is incorrect. Bcl6 is actually associated with follicular helper T cells (Tfh), not TH2 cells. Instead, TH2 cells are characterized by the expression of GATA3.

Therefore, the option 'TH2: Bcl6' is incorrectly matched and does not correspond to the known characterization of the TH2 subset of T cells.

User Mpiktas
by
6.5k points