Question

Which of the following statements is false?

1) In the presence of a survival signal, Akt is phosphorylated.
2) In the absence of a survival signal, Bad inhibits the cell-death inhibitor protein BCl₂.
3) In the presence of a survival signal, the cell-death inhibitory protein BCl₂ is active.
4) In the absence of a survival signal, Bad is phosphorylated.

Answer 1

The false statement is option 1: In the presence of a survival signal, Akt is phosphorylated. Akt is activated by phosphorylation in response to survival signals and promotes cell survival and inhibits apoptosis by phosphorylating and inactivating pro-apoptotic proteins.

Step-by-step explanation:

The false statement is option 1, 'In the presence of a survival signal, Akt is phosphorylated.'

Akt, also known as protein kinase B, is a protein kinase that is activated by phosphorylation in response to growth factors and survival signals. It plays a role in promoting cell survival and inhibiting apoptosis (cell death).

Therefore, in the presence of a survival signal, Akt is activated by phosphorylation, not inhibited. This activation of Akt promotes cell survival and inhibits apoptosis by phosphorylating and inactivating pro-apoptotic proteins, such as Bad.