Final answer:
An individual with the appropriate number of chromosomes for their species is called euploid, while an individual with an error in chromosome number is described as aneuploid. Monosomic human zygotes missing any one copy of an autosome fail to develop to birth due to the lack of essential genes. Trisomic individuals have an excess in gene dose and often suffer from functional challenges and preclude development.
Step-by-step explanation:
An individual with the appropriate number of chromosomes for their species is called euploid; in humans, euploidy corresponds to 22 pairs of autosomes and one pair of sex chromosomes. An individual with an error in chromosome number is described as aneuploid, a term that includes monosomy (loss of one chromosome) or trisomy (gain of an extraneous chromosome).
Monosomic human zygotes missing any one copy of an autosome invariably fail to develop to birth because they lack essential genes. Most autosomal trisomies also fail to develop to birth; however, duplications of some smaller chromosomes (13, 15, 18, 21, or 22) can result in offspring that survive for several weeks to many years. Trisomic individuals suffer from an excess in gene dose, as they may synthesize too much of the gene products encoded by that chromosome.
This extra dose of specific genes can lead to a number of functional challenges and often precludes development. The most common trisomy among viable births is that of chromosome 21, which corresponds to Down Syndrome. Individuals with this inherited disorder are characterized by short stature and stunted digits, facial distinctions that include a broad skull and large tongue, and significant developmental delays. The incidence of Down syndrome is correlated with maternal age; older women are more likely to become pregnant with fetuses carrying the trisomy 21 genotype.