Question

Pyruvate is an important metabolic intermediate that can be converted into several other compounds, depending on which enzyme is catalyzing the reaction. Which of the following cannot be produced from pyruvate in a single enzyme-catalyzed reaction?

1) Acetyl-CoA
2) Lactate
3) Oxaloacetate
4) Glucose

Answer 1

Glucose cannot be produced from pyruvate in a single enzyme-catalyzed reaction, unlike acetyl-CoA, lactate, or oxaloacetate, which can be formed from pyruvate by specific individual enzymes. so, option 1 is the correct answer.

Step-by-step explanation:

Among the choices given, glucose cannot be produced from pyruvate in a single enzyme-catalyzed reaction. Pyruvate can be converted into acetyl-CoA by the enzyme pyruvate dehydrogenase in an oxidative decarboxylation reaction that occurs in the mitochondrial matrix. Likewise, it can be converted to lactate in the cytoplasm by lactate dehydrogenase under anaerobic conditions. The enzyme pyruvate carboxylase catalyzes the formation of oxaloacetate from pyruvate. However, the conversion of pyruvate into glucose involves a complex series of reactions known as gluconeogenesis, which requires multiple enzymes and steps rather than a single enzyme-catalyzed reaction.

Pyruvate cannot be directly converted into glucose in a single enzyme-catalyzed reaction.

Pyruvate can be converted into several compounds depending on the enzyme that catalyzes the reaction. However, pyruvate cannot be directly converted into glucose in a single enzyme-catalyzed reaction. Glucose is formed from pyruvate through a series of enzymatic reactions in a process called gluconeogenesis.