Final answer:
Option 1.
To be passed down to the next generation, a mutation must occur in the germ line (gametes). Germline mutations affect the offspring's entire cellular structure, while somatic mutations do not get passed on.
Step-by-step explanation:
For a mutation to be passed down to the next generation, it must occur in the germ line.
Germline mutations occur in the sex cells, which are the gametes (sperm and eggs), and can be transmitted to offspring, resulting in every cell of the offspring containing these mutations.
Conversely, somatic mutations occur in other cells of the body and cannot be passed on to offspring as they are confined to the original organism and do not affect the germ cells that give rise to the next generation.
It is essential to emphasize that only mutations in the germ line have the potential to be inherited by the next generation.
Please mention the correct option in the final answer: 1) germ.