Question

Which of the following experimental questions is least suited to testing through microarray analysis?

1) Are there groups of genes that behave as though they may be under the control of a common regulator or regulators?
2) Are there genes that are expressed in developing rat embryos that are not expressed in adult rats?
3) Which human genes are abnormally expressed in lung tumors?
4) How does the number of genes in the human genome compare to the number of genes in the chimpanzee genome?

Answer 1

Option 4.

The experimental question least suited for microarray analysis is about comparing the total number of genes between the human and chimpanzee genomes, which is not an expression analysis that microarrays are designed for.

Step-by-step explanation:

The experimental question that is least suited to testing through microarray analysis is 'How does the number of genes in the human genome compare to the number of genes in the chimpanzee genome?'.

Microarray analysis is chiefly used to examine gene expression patterns between samples, such as identifying groups of genes under common regulatory control, finding genes that are expressed at different developmental stages, or pinpointing aberrant gene expression in diseases like cancer.

However, comparing the total number of genes between human and chimpanzee genomes involves genomic sequencing and bioinformatics comparisons rather than expression analysis.

Please mention correct option in final answer: The correct option is 4) How does the number of genes in the human genome compare to the number of genes in the chimpanzee genome?