Final answer:
Nucleotide excision repair on a multi-enzyme complex involves the recognition and removal of damaged bases by repair enzymes. The damaged segment is replaced with correctly paired nucleotides and the gap is sealed with DNA ligase.
Step-by-step explanation:
Nucleotide excision repair is a process in which enzymes replace incorrect bases in DNA. It involves the formation of a multi-enzyme complex. The first step is the recognition of bulky, helix-distorting changes or single-strand breaks by repair enzymes such as UvrABC endonuclease. These enzymes make a cut on both the 3' and 5' ends of the damaged base and remove a segment of DNA. The segment is then replaced with correctly paired nucleotides by the action of DNA polymerase. Once the bases are filled in, a phosphodiester linkage is formed to seal the gap using DNA ligase.