Question

RecA and RAD 51 are involved in which step of homologous recombination?

1) Formation of single-stranded DNA
2) Search for homologous DNA sequence
3) Strand invasion and DNA synthesis
4) Resolution of Holliday junction

Answer 1

RecA and RAD51 play a crucial role in strand invasion and DNA synthesis during homologous recombination, facilitating the repair of DNA double-strand breaks and maintaining genetic stability.Hence, the correct answer is option 3.

Step-by-step explanation:

RecA and RAD51 are critical proteins involved in homologous recombination, particularly in strand invasion and DNA synthesis. These proteins facilitate the search for homologous DNA sequences and enable the invading single-stranded DNA to pair with its complementary strand in the homologous duplex DNA. This step is crucial for error-free repair of DNA double-stranded breaks. RecA, found in bacteria, and its eukaryotic homolog RAD51, form filaments on single-stranded DNA that search for and invade homologous sequences, allowing the recombination process to proceed. These proteins are thus central to maintaining genetic stability by accurate repair of DNA during cell division.