Question

A polypeptide binds (E) at a location other than the active site, and causes a conformational change at the active site such that the (S) cannot bind. With regard to regulation, what specific type of regulator is the polypeptide? What type of regulation is this?

Answer 1

The polypeptide that binds at an allosteric site and inhibits substrate binding by inducing a conformational change is an allosteric inhibitor, and this mechanism is known as allosteric regulation.

Step-by-step explanation:

The type of regulator the polypeptide represents in the scenario described is an allosteric inhibitor. This is because the polypeptide binds to an enzyme at a location other than the active site and causes a conformational change to the active site, making it less efficient for substrate binding. This form of regulation is known as allosteric regulation, which can be either negative, in the case of allosteric inhibitors, or positive, in the case of allosteric activators, which enhance the enzyme's function by increasing its affinity for the substrate.