Final answer:
In the context of a publisher's print design, registration refers to registering the design with a publishing house. Option 2.
Step-by-step explanation:
In the context of a publisher's print design, registration refers to registering the design with a publishing house(2). When a publisher registers a design, it typically means that the design is being submitted for consideration or approval by the publishing house for printing and distribution. This process ensures that the design meets the publisher's standards and requirements.