Final answer:
Historically, Beriberi signifies a deficiency of vitamin B1 (thiamine), characterized by neurological and cardiovascular symptoms. The correct option is 2) Vitamin B1
Step-by-step explanation:
Beriberi is historically the classic deficiency state of vitamin B1. This condition is characterized by symptoms such as polyneuritis, edema, cardiovascular changes, weakness, muscular atrophy, and gastrointestinal disorders. There are two types of Beriberi: Dry Beriberi, where nervous symptoms predominate, and Wet Beriberi, where symptoms are associated with edema and serous effusions.
The importance of thiamine also referred to as vitamin B1, was highlighted by the work of Takaki Kanehiro and Christiaan Eijkman, who understood the relationship between diet and disease through their observation and research on populations consuming polished rice and those consuming unpolished rice, respectively. The correct option is 2) Vitamin B1