Final answer:
The response to selection of a trait is calculated by multiplying the strength of selection by the heritability of the trait. Heritability accounts for genetic variance observed in a population's phenotype (option 4).
Step-by-step explanation:
The response to selection of a trait can be calculated as represented in option 4, which is by multiplying the strength of selection by the heritability. Heritability is a measure of how much of the variability of a phenotypic trait in a population is due to genetic differences among individuals. When selection acts on a trait, the response to that selection is determined by these genetic variances.
Applying this knowledge, if we have a population where a particular trait is under selection, the change in the trait’s phenotype from one generation to the next (the response to selection) can be estimated by the product of the strength of the selection and the heritability. For instance, if the heritability of a trait like plant height is high, and we apply strong selection for increased height, the expected response will be a greater increase in average plant height in the next generation.
Hence, the answer is option 4.