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Explain how the Ca²+ pump is ATP-driven?

User Lazywei
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Final answer:

The Ca²⁺ pump is an ATP-driven ion pump that transports calcium ions against their concentration gradient using energy obtained from the hydrolysis of ATP. This energy induces conformational changes in the pump, allowing for the transport of ions, a process crucial for maintaining cellular ion gradients.

Step-by-step explanation:

The Ca²⁺ pump is an ATP-driven ion pump that actively transports calcium ions out of the cell cytoplasm into the extracellular fluid or into intracellular compartments such as the sarcoplasmic reticulum in muscle cells. This active transport requires energy because it moves calcium ions against their concentration gradient. The pump operates through a mechanism similar to the sodium-potassium pump (Na⁺/K⁺ pump), which is also an example of an ATPase.

Here's the general process of how the Ca²⁺ pump functions:

  1. ATP binds to the pump, providing the energy needed for the pump's activity.
  2. The energy from ATP is used to phosphorylate the pump, a process called phosphorylation, which induces a conformational change in the protein.
  3. This change in shape allows the pump to transport calcium ions across the cell membrane to the exterior or into intracellular stores.
  4. Once the transport is complete, the pump returns to its original conformation, ready to start another cycle.

The hydrolysis of ATP releases energy that is used by the pump to move ions from an area of lower concentration to an area of higher concentration, maintaining the ion gradients essential for cellular processes.

User Akcasoy
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