Final answer:
The term associated with substrate activation in enzymatic reactions that is not correct is neutron transfer. Other mechanisms like bond distortion, proton transfer, electron transfer, and intramolecular hydrogen bonding are all valid processes involved in the catalytic activity of enzymes.
Step-by-step explanation:
The question refers to the mechanism of substrate activation in enzymatic reactions. Substrate activation is associated with several mechanisms including bond distortion, proton transfer, which involves electron-pair transfer, electron transfer, and intramolecular hydrogen bonding. These are all ways that enzymes can lower the activation energy of a reaction, facilitating the conversion of substrates into products. However, neutron transfer is not a recognized process in enzymatic substrate activation, making it the correct answer.
Enzymes can induce an induced-fit model, where binding of the substrate to the enzyme causes a change in the enzyme's structure, which may include bond distortion or a strain in the shape of the active site. The enzyme and substrate may form transient covalent bonds as part of covalent catalysis. Hydrogen bonding, ionic interactions, and other noncovalent interactions, like London dispersion forces, are also involved in the binding of the substrate to the active site and the stabilization of the transition state.