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What are the characteristics of BRCA1?

1) Located on a specific chromosome
2) Associated with ovarian cancer and breast cancer
3) Associated with Lynch syndrome type II
4) Associated with Peutz-Jeghers syndrome

1 Answer

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Final answer:

Characteristics of BRCA1 include its location on chromosome 17 and its association with an increased risk of breast and ovarian cancer. BRCA1 is not associated with Lynch syndrome type II or Peutz-Jeghers syndrome. BRCA1 and BRCA2 are tumor suppressor genes on autosomal chromosomes, not linked genes, and mutations can lead to cancer, although environmental factors also contribute to risk.

Step-by-step explanation:

The characteristics of BRCA1 are:

  1. Located on a specific chromosome: BRCA1 is located on chromosome 17.
  2. Associated with ovarian cancer and breast cancer: Mutations in BRCA1 greatly increase the risk of breast and ovarian cancer in women.
  3. It is not associated with Lynch syndrome type II: This syndrome is associated with different genetic mutations.
  4. It is not associated with Peutz-Jeghers syndrome: This condition is linked to a mutation in the STK11 gene, not BRCA1.

The BRCA1 and BRCA2 genes normally serve as tumor suppressor genes, which help to prevent cancer by making proteins that help the cell repair DNA. When these genes are mutated, they no longer function properly, which can lead to uncontrolled cell growth and cancer. These genes, while increasing the risk of cancer, do not guarantee the development of cancer, and environmental factors also play a role.

BRCA1 and BRCA2 are not considered linked genes. They are located on different chromosomes -- BRCA1 on chromosome 17 and BRCA2 on chromosome 13, which are autosomal chromosomes, meaning that they are not sex chromosomes. Therefore, both men and women can inherit and pass on mutations in these genes.

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