Question

BiP is a molecular chaperone that is essential for the translocation of secreted peptides into the lumen of the ER. Because it is a chaperone, it is important for ______?

1) protein folding
2) DNA replication
3) cell division
4) photosynthesis

Answer 1

BiP is a chaperone important for protein folding, ensuring proteins achieve their functional three-dimensional structure.

Step-by-step explanation:

The molecular chaperone BiP is vital for protein folding within the lumen of the Endoplasmic Reticulum (ER). As a chaperone, BiP assists in the proper folding of polypeptides and the assembly of multiple subunits into a distinct three-dimensional structure. This process is essential for ensuring that proteins reach their functional conformation, which is crucial for the proteins to perform their biological roles effectively. The role of BiP as a molecular chaperone is important for protein folding. It helps in guiding the folding process of secreted peptides in the endoplasmic reticulum (ER) by preventing misfolding or aggregation of the proteins. BiP ensures that the proteins attain their proper three-dimensional structure, which is crucial for their functionality.

BiP, like other heat shock proteins (HSPs), helps in managing the correct folding of proteins during their synthesis and translocation across the ER membrane. Moreover, without the assistance of molecular chaperones like BiP, proteins may misfold, leading to aggregation and potential cellular dysfunction.